Surveillance of the Tumor Mutanome by T Cells during Progression from Primary to 1 Recurrent Ovarian Cancer 2 3 Authors 4 5
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چکیده
Surveillance of the tumor mutanome by T cells during progression from primary to 1 recurrent ovarian cancer 2 3 Authors 4 5 Darin A. Wick, 6 John R. Webb, 7 Julie S. Nielsen, 8 Spencer D. Martin, 9 David R. Kroeger, 10 Katy Milne, 11 Mauro Castellarin, 12 Kwame Twumasi-Boateng, 13 Peter H. Watson, 14 Rob A. Holt, 15 Brad H. Nelson, 16 17 Trev and Joyce Deeley Research Centre, British Columbia Cancer Agency, Victoria, British 18 Columbia, Canada, 19 Department of Biochemistry and Microbiology, University of Victoria, Victoria, British 20 Columbia, Canada, 21 Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British 22 Columbia, Canada. 23 Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, 24 Canada. 25 Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British 26 Columbia, Canada. 27 Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, 28 British Columbia, Canada, 29 * Address correspondence to Dr. Brad H. Nelson, Trev and Joyce Deeley Research Centre, 30 British Columbia Cancer Agency, Victoria, BC, Canada, V8R 6V5. (Tel) 250-519-5705, (FAX) 31 250-519-2040, (email) [email protected] 32 33 Disclosure of Potential Conflicts of Interest: 34 35 The authors have no potential conflicts of interest to disclose. 36
منابع مشابه
Surveillance of the tumor mutanome by T cells during progression from primary
Surveillance of the tumor mutanome by T cells during progression from primary to 1 recurrent ovarian cancer 2 3 Authors 4 5 Darin A. Wick, 6 John R. Webb, 7 Julie S. Nielsen, 8 Spencer D. Martin, 9 David R. Kroeger, 10 Katy Milne, 11 Mauro Castellarin, 12 Kwame Twumasi-Boateng, 13 Peter H. Watson, 14 Rob A. Holt, 15 Brad H. Nelson, 16 17 Trev and Joyce Deeley Research Centre, British Columbia C...
متن کاملSurveillance of the tumor mutanome by T cells during progression from primary to recurrent ovarian cancer.
PURPOSE Cancers accumulate mutations over time, each of which brings the potential for recognition by the immune system. We evaluated T-cell recognition of the tumor mutanome in patients with ovarian cancer undergoing standard treatment. EXPERIMENTAL DESIGN Tumor-associated T cells from 3 patients with ovarian cancer were assessed by ELISPOT for recognition of nonsynonymous mutations identifi...
متن کاملHuman Cancer Biology Surveillance of the Tumor Mutanome by T Cells during Progression from Primary to Recurrent Ovarian Cancer
Purpose:Cancers accumulatemutations over time, each of which brings the potential for recognition by the immune system.We evaluated T-cell recognitionof the tumormutanome inpatientswithovarian cancer undergoing standard treatment. Experimental Design: Tumor-associated T cells from 3 patients with ovarian cancer were assessed by ELISPOT for recognition of nonsynonymous mutations identified by wh...
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Background: CD8+ cytotoxic T lymphocytes have been recently divided based on their cytokine expression profile. Objective: To evaluate the percentages of CD8+ lymphocytes and their effector subsets including Tc1, Tc2 and Tc17 in the tumor draining lymph nodes (TDLNs) of patients with breast cancer. Methods: Single cell suspensions were obtained from TDLNs of 42 patients with breast cancer. Stai...
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